作者
Irena Kostova
发表日期
2005/11/1
来源
Current Medicinal Chemistry-Anti-Cancer Agents
卷号
5
期号
6
页码范围
591-602
出版商
Bentham Science Publishers
简介
The application of inorganic chemistry to medicine is a rapidly developing field, and novel therapeutic and diagnostic metals and metal complexes are now having an impact on medical practice. Advances in biocoordination chemistry are crucial for improving the design of compounds to reduce toxic side effects and understand their mechanisms of action. A lot of metal-based drugs are widely used in the treatment of cancer. The clinical success of cisplatin and other platinum complexes is limited by significant side effects acquired or intrinsic resistance. Therefore, much attention has focused on designing new coordination compounds with improved pharmacological properties and a broader range of antitumor activity. Strategies for developing new anticancer agents include the incorporation of carrier groups that can target tumor cells with high specificity. Also of interest is to develop complexes that bind to DNA in a …
引用总数
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学术搜索中的文章
I Kostova - Current Medicinal Chemistry-Anti-Cancer Agents, 2005