作者
Mats Remberger, Malin Ackefors, Sofia Berglund, Ola Blennow, Göran Dahllöf, Aldona Dlugosz, Karin Garming-Legert, Jens Gertow, Britt Gustafsson, Moustapha Hassan, Zuzana Hassan, Dan Hauzenberger, Hans Hägglund, Helen Karlsson, Lena Klingspor, Gunilla Kumlien, Katarina Le Blanc, Per Ljungman, Maciej Machaczka, Karl-Johan Malmberg, Hanns-Ulrich Marschall, Jonas Mattsson, Richard Olsson, Brigitta Omazic, Darius Sairafi, Marie Schaffer, Britt-Marie Svahn, Petter Svenberg, Lisa Swartling, Attila Szakos, Michael Uhlin, Mehmet Uzunel, Emma Watz, Annika Wernerson, Agneta Wikman, Ann-Charlotte Wikström, Jacek Winiarski, Olle Ringdén
发表日期
2011/11/1
期刊
Biology of Blood and Marrow Transplantation
卷号
17
期号
11
页码范围
1688-1697
出版商
Elsevier
简介
We analyzed the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) over the past 2 decades. Between 1992 and 2009, 953 patients were treated with HSCT, mainly for a hematologic malignancy. They were divided according to 4 different time periods of treatment: 1992 to 1995, 1996 to 2000, 2001 to 2005, and 2006 to 2009. Over the years, many factors have changed considerably regarding patient age, diagnosis, disease stage, type of donor, stem cell source, genomic HLA typing, cell dose, type of conditioning, treatment of infections, use of granulocyte-colony stimulating factor (G-CSF), use of mesenchymal stem cells, use of cytotoxic T cells, and home care. When we compared the last period (2006-2009) with earlier periods, we found slower neutrophil engraftment, a higher incidence of acute graft-versus-host disease (aGVHD) of grades II-IV, and less chronic GVHD (cGHVD). The incidence …
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M Remberger, M Ackefors, S Berglund, O Blennow… - Biology of Blood and Marrow Transplantation, 2011