作者
Atul Deodhar, Désirée van der Heijde, Lianne S Gensler, Tae-Hwan Kim, Walter P Maksymowych, Mikkel Østergaard, Denis Poddubnyy, Helena Marzo-Ortega, Louis Bessette, Tetsuya Tomita, Ann Leung, Maja Hojnik, Gaia Gallo, Xiaoqi Li, David Adams, Hilde Carlier, Joachim Sieper, Frederic Morin, Proton Rahman, Federico Ariel, Alberto Berman, Judith Carrio, Eleonora Lucero, Jose Maldonado Cocco, Rodolfo Pardo Hidalgo, Jorge Velasco, Diego O Viola, Johannes Grisar, Heinrich Resch, Clemens Scheinecker, Ana Claudia Melazzi, Luis Roimicher, Antonio Scafuto Scotton, Aaron Alejandro Barrera Rodriguez, Francisco Fidencio Cons Molina, Sergio Duran Barragan, Cassandra M Skinner, Cesar Francisco Pacheco Tena, Cesar Ricardo Ramos Remus, Juan Cruz Rizo Rodriguez, Seung-Jae Hong, Seong Wook Kang, Chang Keun Lee, Eun Bong Lee, Sang Heon Lee, Min-Chan Park, Sang-Hoon Lee, Eva Dokoupilova, Zdenek Dvorak, Martina Malcova, Karel Pvelka, Kari K Eklund, Pentti Jarvinen, Anna Karjalainen, Leena Paimela, Yoshinori Taniguchi, Tokutaro Tsuda, Kurisu Tada, Hiroaki Dobashi, Kentaro Inui, Yukitaka Ueki, Yoshifuji Matsumoto, Kazuhiro Hatta, Tatsuya Atsumi, Hitoshi Goto, Shigeru Honjo, Kiyoshi Matsui, Yuya Takakubo, Gunther Neeck, Sylke Wagner, Jürgen Braun, Tomasz Blicharshi, Anna Dudek, Pawel Hrycai, Rafal Plebanski, Janina Drabiszcak-Piatkowska, Jan Brzezicki, Marek Krogulec, Daniela Opris-Belinski, Ana Maria Ramazan, Luminita Tronaru, Marleen G van de Sande, Galina Matsievskaya, Evgeniya Schmidt, Marina Stanislav, Sergey Yakushin, Olga Ershova, Andrey Rebroy, Melvin A Churchill, Kathleen P Flint, Maria Greenwald, Mary P Howell, Jeffrey L Kaine, Alan Kivitz, Steven J Klein, Eric C Mueller, Eric A Peters, Roel Querubin, Michael E Sayers, Craig D Scoville, Joseph C Shanahan, Richard Roseff, John E Hull, Jyothi R Mallepalli, Mohamed B Sebai, Steven C Kimmel, David H Goddard, Philip J Mease, Mark D Harris, Arthur R Mabaquiao, Roger J Diegel, Christine Thai, Tania L Rivera, Amarilis Perez-De Jesus, Oscar Soto-Raices, Ramon Toro-Torres, Carlos Pantojas
发表日期
2020/1/4
期刊
The Lancet
卷号
395
期号
10217
页码范围
53-64
出版商
Elsevier
简介
Background
Ixekizumab, a high-affinity interleukin-17A (IL-17A) monoclonal antibody, has previously shown efficacy in radiographic axial spondyloarthritis (also known as ankylosing spondylitis). We aimed to evaluate the efficacy and safety of ixekizumab, an IL-17 inhibitor, in non-radiographic axial spondyloarthritis. Here, we report the primary results of COAST-X.
Methods
COAST-X was a 52-week, randomised, double-blind, placebo-controlled, parallel-group study done at 107 sites in 15 countries in Europe, Asia, North America, and South America. Eligible participants were adults (aged ≥18 years) with active axial spondyloarthritis without definite radiographic sacroiliitis (non-radiographic axial spondyloarthritis), objective signs of inflammation (via MRI or C-reactive protein), and an inadequate response or intolerance to non-steroidal anti-inflammatory drugs (NSAIDs). Patients were randomly assigned (1:1:1) to …
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A Deodhar, D van der Heijde, LS Gensler, TH Kim… - The Lancet, 2020