作者
Atul Deodhar, Lianne S Gensler, Joachim Sieper, Michael Clark, Cesar Calderon, Yuhua Wang, Yiying Zhou, Jocelyn H Leu, Kim Campbell, Kristen Sweet, Diane D Harrison, Elizabeth C Hsia, Désirée van der Heijde, Frederico Ariel, Cecilia Adma Asnal, Alberto Berman, Gustavo Citera, Graciela Rodriguez, Veronica Gabriela Savio, Paul Bird, Hedley Griffiths, David Nicholls, Maureen Rischmueller, Jane Zochling, Kurt De Vlam, Michel Malaise, Adrien Nzeusseu Toukap, Filip Van den Bosch, Johan Vanhoof, Rubens Bonfiglioli, Mauro Keiserman, Antonio Scafuto Scotton, Ricardo Xavier, Antonio Carlos Ximenes, Assen Atanasov, Ivan Goranov, Ivan Kazmin, Rodina Nestorova Licheva, Nikolay Nikolov, Boycho Oparanov, Rumen Stoilov, Louis Bessette, Jude Rodrigues, Ladislav Bortilik, Eva Dokoupilova, Zdenek Dvoarak, Dagmar Galatikova, Petr Nemec, Lucie Podrazilova, Gabriela Simkova, Zuzana Stejfova, Radka Moravcova, Petr Vitek, Alain Cantagrel, Athan Baillet, Beatrice Banneville, Bernard Combe, Maxime Breban, Minh Nguyen, Philippe Goupille, Juergen Braun, Andrea Everding, Joern Kekow, Ramona Koenig, Andrea Rubbert‐Roth, Torsten Witte, Attila Bartha, Edit Drescher, Kata Kerekes, Attila Kovacs, Judit Pulai, Bernadette Rojkovich, Sandor Szanto, Edit Toth, Hilario Avila, Igancio Garcia de la Torre, Fedra Irazoque, Marco Maradiaga, Cesar Pacheco, Marek Brzosko, Anna Dudek, Slawomir Jeka, Marek Krogulec, Brygida Kwiatkowska, Piotr Wiland, Rafal Wojciechowski, Agnieszka Zielinska, Helena Santos, Olga Bugrova, Valery Christyakov, Vladimir Gorbunov, Elena Ilivanova, Elena Zemerova, Rima Kamalova, Tatyana Kameneva, Galina Macievskaya, Irina Marusenko, Alexey Maslyansky, Svetlana Myasoedova, Leisan Myasoutova, Boris Nemtsov, Olga Nesmeyanova, Tatyana Plaksina, Tatyana Pokrovskaya, Svetlana Polyakova, Andrey Rebrov, Liudmila Savina, Svetlana Smakotina, Marina Stanislav, Olga Ukhanova, Irina Vinogradova, Elena Zonova, Han Joo Baek, Tae‐Hwan Kim, ChangKeun Lee, SangHeon Lee, Sang‐Hoon Lee, Shin‐Seok Lee, Sung‐Hwan Park, YeongWook Song, Chang‐Hee Suh, Juan Amarelo Ramos, Franciso Javier Blanco, Eduardo Collantes, Miguel Consuelo Diaz, Maria Luz Garcia Vivar, Jordi Gratacos, Xavier Juanola, Der‐Yuan Chen, Hsiang‐Cheng Chen, Kun‐Hung Chen, Ying‐Chou Chen, Ying‐Ming Chiu, Shue‐Fen Luo, Shih‐Tzu Tsai, Jui‐Cheng Tseng, Cheng‐Chung Wei, Meng‐Yu Weng, Orest Abrahamovych, Dmytro Reshotko, Oleksandr Golovchenko, Ihor Hospodarsky, Oleg Iaremenko, Olena Levchenko, Oleksandr Dudnyk, Olena Garmish, Olena Grishyna, Galyna Protsenko, Dmytro Rekalov, Svitlana Smiyan
发表日期
2019/2
期刊
Arthritis & Rheumatology
卷号
71
期号
2
页码范围
258-270
简介
Objective
To evaluate the efficacy and safety of ustekinumab in 3 randomized, placebo‐controlled studies in patients with axial spondyloarthritis (SpA). Studies 1 and 2 included patients with radiographic axial SpA (anti–tumor necrosis factor [anti‐TNF]–naive patients and patients with inadequate response or intolerance to anti‐TNF, respectively); study 3 patients had nonradiographic axial SpA.
Methods
In all 3 studies, patients were randomly assigned (1:1:1) to receive subcutaneous ustekinumab at 45 mg or 90 mg or placebo up to 24 weeks, after which placebo‐treated patients were rerandomized to receive ustekinumab at 45 mg or 90 mg. The primary end point in studies 1 and 2 was the proportion of patients who met the Assessment of SpondyloArthritis international Society criteria for 40% improvement in disease activity (achieved an ASAS40 response). The primary end point in study 3 was the proportion of …
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A Deodhar, LS Gensler, J Sieper, M Clark, C Calderon… - Arthritis & Rheumatology, 2019