作者
Matthias Briel, Maureen Meade, Alain Mercat, Roy G Brower, Daniel Talmor, Stephen D Walter, Arthur S Slutsky, Eleanor Pullenayegum, Qi Zhou, Deborah Cook, Laurent Brochard, Jean-Christophe M Richard, Francois Lamontagne, Neera Bhatnagar, Thomas E Stewart, Gordon Guyatt
发表日期
2010/3/3
来源
Jama
卷号
303
期号
9
页码范围
865-873
出版商
American Medical Association
简介
Context
Trials comparing higher vs lower levels of positive end-expiratory pressure (PEEP) in adults with acute lung injury or acute respiratory distress syndrome (ARDS) have been underpowered to detect small but potentially important effects on mortality or to explore subgroup differences.
Objectives
To evaluate the association of higher vs lower PEEP with patient-important outcomes in adults with acute lung injury or ARDS who are receiving ventilation with low tidal volumes and to investigate whether these associations differ across prespecified subgroups.
Data Sources
Search of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (1996-January 2010) plus a hand search of conference proceedings (2004-January 2010).
Study Selection
Two reviewers independently screened articles to identify studies randomly assigning adults with acute lung injury or ARDS to treatment with higher vs lower …
引用总数
学术搜索中的文章
M Briel, M Meade, A Mercat, RG Brower, D Talmor… - Jama, 2010