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Aberrations in maternal thyroid function and autoimmunity during pregnancy have been associated with negative obstetric outcome. In Denmark, a national iodine fortification program was implemented in the year 2000 with the aim to alleviate the mild-moderate iodine deficiency. Following the iodine implementation, there has been an increase in thyroid autoimmunity in the background population. This study investigates the thyroid status of pregnant Danish women following the iodine fortification program, and a possible association with preterm delivery.

Historical cohort study of 1278 randomly selected pregnant Danish women attending the national Down's syndrome screening program.

The main outcome measures were thyroid status according to laboratory- and gestational-age-specific reference intervals, and association …