作者
Freddy JK Toloza, Arash Derakhshan, Tuija Männistö, Sofie Bliddal, Polina V Popova, David M Carty, Liangmiao Chen, Peter Taylor, Lorena Mosso, Emily Oken, Eila Suvanto, Sachiko Itoh, Reiko Kishi, Judit Bassols, Juha Auvinen, Abel López-Bermejo, Suzanne J Brown, Laura Boucai, Aya Hisada, Jun Yoshinaga, Ekaterina Shilova, Elena N Grineva, Tanja GM Vrijkotte, Jordi Sunyer, Ana Jiménez-Zabala, Isolina Riaño-Galan, Maria-Jose Lopez-Espinosa, Larry J Prokop, Naykky Singh Ospina, Juan P Brito, Rene Rodriguez-Gutierrez, Erik K Alexander, Layal Chaker, Elizabeth N Pearce, Robin P Peeters, Ulla Feldt-Rasmussen, Mònica Guxens, Leda Chatzi, Christian Delles, Jeanine E Roeters van Lennep, Victor JM Pop, Xuemian Lu, John P Walsh, Scott M Nelson, Tim IM Korevaar, Spyridoula Maraka
发表日期
2022/4/1
来源
The Lancet Diabetes & Endocrinology
卷号
10
期号
4
页码范围
243-252
出版商
Elsevier
简介
Background
Adequate maternal thyroid function is important for an uncomplicated pregnancy. Although multiple observational studies have evaluated the association between thyroid dysfunction and hypertensive disorders of pregnancy, the methods and definitions of abnormalities in thyroid function tests were heterogeneous, and the results were conflicting. We aimed to examine the association between abnormalities in thyroid function tests and risk of gestational hypertension and pre-eclampsia.
Methods
In this systematic review and meta-analysis of individual-participant data, we searched MEDLINE (Ovid), Embase, Scopus, and the Cochrane Database of Systematic Reviews from date of inception to Dec 27, 2019, for prospective cohort studies with data on maternal concentrations of thyroid-stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase (TPO) antibodies, individually or in combination, as …
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