作者
Joris AJ Osinga, Arash Derakhshan, Glenn E Palomaki, Ghalia Ashoor, Tuija Männistö, Spyridoula Maraka, Liangmiao Chen, Sofie Bliddal, Xuemian Lu, Peter N Taylor, Tanja GM Vrijkotte, Fang-Biao Tao, Suzanne J Brown, Farkhanda Ghafoor, Kris Poppe, Flora Veltri, Lida Chatzi, Bijay Vaidya, Maarten AC Broeren, Beverley M Shields, Sachiko Itoh, Lorena Mosso, Polina V Popova, Anna D Anopova, Reiko Kishi, Ashraf Aminorroaya, Maryam Kianpour, Abel López-Bermejo, Emily Oken, Amna Pirzada, Marina Vafeiadi, Wichor M Bramer, Eila Suvanto, Jun Yoshinaga, Kun Huang, Judit Bassols, Laura Boucai, Ulla Feldt-Rasmussen, Elena N Grineva, Elizabeth N Pearce, Erik K Alexander, Victor JM Pop, Scott M Nelson, John P Walsh, Robin P Peeters, Layal Chaker, Kypros H Nicolaides, Mary E D’Alton, Tim IM Korevaar
发表日期
2022/10/1
来源
The Journal of Clinical Endocrinology & Metabolism
卷号
107
期号
10
页码范围
2925-2933
出版商
Oxford University Press
简介
Context
Interpretation of thyroid function tests during pregnancy is limited by the generalizability of reference intervals between cohorts due to inconsistent methodology.
Objective
(1) To provide an overview of published reference intervals for thyrotropin (TSH) and free thyroxine (FT4) in pregnancy, (2) to assess the consequences of common methodological between-study differences by combining raw data from different cohorts.
Methods
(1) Ovid MEDLINE, EMBASE, and Web of Science were searched until December 12, 2021. Studies were assessed in duplicate. (2) The individual participant data (IPD) meta-analysis was performed in participating cohorts in the Consortium on Thyroid and Pregnancy.
Results
(1) Large between-study methodological differences were identified, 11 of 102 included studies were in accordance with …
引用总数
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