作者
Liang-Bo Wang, Alla Karpova, Marina A Gritsenko, Jennifer E Kyle, Song Cao, Yize Li, Dmitry Rykunov, Antonio Colaprico, Joseph H Rothstein, Runyu Hong, Vasileios Stathias, MacIntosh Cornwell, Francesca Petralia, Yige Wu, Boris Reva, Karsten Krug, Pietro Pugliese, Emily Kawaler, Lindsey K Olsen, Wen-Wei Liang, Xiaoyu Song, Yongchao Dou, Michael C Wendl, Wagma Caravan, Wenke Liu, Daniel Cui Zhou, Jiayi Ji, Chia-Feng Tsai, Vladislav A Petyuk, Jamie Moon, Weiping Ma, Rosalie K Chu, Karl K Weitz, Ronald J Moore, Matthew E Monroe, Rui Zhao, Xiaolu Yang, Seungyeul Yoo, Azra Krek, Alexis Demopoulos, Houxiang Zhu, Matthew A Wyczalkowski, Joshua F McMichael, Brittany L Henderson, Caleb M Lindgren, Hannah Boekweg, Shuangjia Lu, Jessika Baral, Lijun Yao, Kelly G Stratton, Lisa M Bramer, Erika Zink, Sneha P Couvillion, Kent J Bloodsworth, Shankha Satpathy, Weiva Sieh, Simina M Boca, Stephan Schürer, Feng Chen, Maciej Wiznerowicz, Karen A Ketchum, Emily S Boja, Christopher R Kinsinger, Ana I Robles, Tara Hiltke, Mathangi Thiagarajan, Alexey I Nesvizhskii, Bing Zhang, DR Mani, Michele Ceccarelli, Xi S Chen, Sandra L Cottingham, Qing Kay Li, Albert H Kim, David Fenyö, Kelly V Ruggles, Henry Rodriguez, Mehdi Mesri, Samuel H Payne, Adam C Resnick, Pei Wang, Richard D Smith, Antonio Iavarone, Milan G Chheda, Jill S Barnholtz-Sloan, Karin D Rodland, Tao Liu, Li Ding, Anupriya Agarwal, Mitual Amin, Eunkyung An, Matthew L Anderson, David W Andrews, Thomas Bauer, Chet Birger, Michael J Birrer, Lili Blumenberg, William E Bocik, Uma Borate, Melissa Borucki, Meghan C Burke, Shuang Cai, Anna P Calinawan, Steven A Carr, Sandra Cerda, Daniel W Chan, Alyssa Charamut, Lin S Chen, David Chesla, Arul M Chinnaiyan, Shrabanti Chowdhury, Marcin P Cieślik, David J Clark, Houston Culpepper, Tomasz Czernicki, Fulvio D'Angelo, Jacob Day, Stephanie De Young, Emek Demir, Saravana Mohan Dhanasekaran, Rajiv Dhir, Marcin J Domagalski, Brian Druker, Elizabeth Duffy, Maureen Dyer, Nathan J Edwards, Robert Edwards, Kimberly Elburn, Matthew J Ellis, Jennifer Eschbacher, Alicia Francis, Stacey Gabriel, Nikolay Gabrovski, Luciano Garofano, Gad Getz, Michael A Gillette, Andrew K Godwin, Denis Golbin, Ziad Hanhan, Linda I Hannick, Pushpa Hariharan, Barbara Hindenach, Katherine A Hoadley, Galen Hostetter, Chen Huang, Eric Jaehnig, Scott D Jewell, Nan Ji, Corbin D Jones, Alcida Karz
发表日期
2021/4/12
期刊
Cancer cell
卷号
39
期号
4
页码范围
509-528. e20
出版商
Elsevier
简介
Glioblastoma (GBM) is the most aggressive nervous system cancer. Understanding its molecular pathogenesis is crucial to improving diagnosis and treatment. Integrated analysis of genomic, proteomic, post-translational modification and metabolomic data on 99 treatment-naive GBMs provides insights to GBM biology. We identify key phosphorylation events (e.g., phosphorylated PTPN11 and PLCG1) as potential switches mediating oncogenic pathway activation, as well as potential targets for EGFR-, TP53-, and RB1-altered tumors. Immune subtypes with distinct immune cell types are discovered using bulk omics methodologies, validated by snRNA-seq, and correlated with specific expression and histone acetylation patterns. Histone H2B acetylation in classical-like and immune-low GBM is driven largely by BRDs, CREBBP, and EP300. Integrated metabolomic and proteomic data identify specific lipid …
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LB Wang, A Karpova, MA Gritsenko, JE Kyle, S Cao… - Cancer cell, 2021