作者
Gabriel Zada, Whitney W Woodmansee, Shakti Ramkissoon, Jordan Amadio, Vania Nose, Edward R Laws
发表日期
2011/2/1
期刊
Journal of neurosurgery
卷号
114
期号
2
页码范围
336-344
出版商
American Association of Neurological Surgeons
简介
Object
The 2004 WHO classification of pituitary adenomas now includes an “atypical” variant, defined as follows: MIB-1 proliferative index greater than 3%, excessive p53 immunoreactivity, and increased mitotic activity. The authors review the incidence of this atypical histopathological subtype and its correlation with tumor subtype, invasion, and surgical features.
Methods
The records of 121 consecutive patients who underwent transsphenoidal surgery for pituitary adenomas during an 18-month period were retrospectively reviewed for evidence of atypical adenomas.
Results
Eighteen adenomas (15%) met the criteria for atypical lesions; 17 (94%) of the 18 were macroadenomas. On imaging, 15 (83%) demonstrated imaging evidence of surrounding invasion, compared with 45% of typical adenomas (p = 0.004). Atypical tumors occurred in 12 female …
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