作者
Enrique F Schisterman, Robert M Silver, Neil J Perkins, Sunni L Mumford, Brian W Whitcomb, Joseph B Stanford, Laurie L Lesher, David Faraggi, Jean Wactawski‐Wende, Richard W Browne, Janet M Townsend, Mark White, Anne M Lynch, Noya Galai
发表日期
2013/11
期刊
Paediatric and perinatal epidemiology
卷号
27
期号
6
页码范围
598-609
简介
Background
Low‐dose aspirin (LDA) has been proposed to improve pregnancy outcomes in couples experiencing recurrent pregnancy loss. However, results from studies of LDA on pregnancy outcomes have been inconsistent, perhaps because most studies evaluated LDA‐initiated post‐conception. The purpose of the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial was to determine whether preconception‐initiated LDA improves livebirth rates in women with one to two prior losses.
Methods
We performed a multicentre, block randomised, double‐blind, placebo‐controlled trial. Study participants were recruited using community‐based advertisements and physician referral to four university medical centres in the US (2006–12). Eligible women were aged 18–40 years actively trying to conceive, with one to two prior losses. Participants were randomised to receive daily LDA (81 mg/day) or a …
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EF Schisterman, RM Silver, NJ Perkins, SL Mumford… - Paediatric and perinatal epidemiology, 2013