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In contrast to the many reports of IL-2 dependent proliferating, helper or killer cell clones¹, there is only a single report of an IL-2 dependent suppressor cell clone², in the mouse. However by the same cloning procedures used to generate human helper cells³, suppressor cell clones to influenza virus could not be generated, and so another strategy was used. Jerne's network hypothesis⁴ proposes that immune regulation results from lymphoid cell receptors recognizing determinants on other lymphoid cell receptors. If this is the case it should be possible to generate regulatory T cell clones against other T cells and we report here the generation of an autologous suppressor cell clone which recognizes and inhibits the function of a human helper T cell clone. Such an autologous suppressor cell clone provides a new approach to understanding the pathways and molecular events involved in immune regulation. Mutual …