作者
Nathalie Vaes, Simone L Schonkeren, Erwin Brosens, Alexander Koch, Conor J McCann, Nikhil Thapar, Robert MW Hofstra, Manon van Engeland, Veerle Melotte
发表日期
2018/10/1
来源
Biochimica et Biophysica Acta (BBA)-General Subjects
卷号
1862
期号
10
页码范围
2140-2151
出版商
Elsevier
简介
Background
The N-Myc Downstream-Regulated Gene (NDRG) family comprises four members that function in cellular processes like proliferation and differentiation. While NDRG1 and NDRG2 are extensively studied, knowledge regarding NDRG3 and NDRG4, despite its recognition as a well-established early-detection marker for colorectal cancer (Cologuard®), is sparse.
Scope of review
To summarize expression, biomarker potential and functional mechanisms of the NDRGs in the developing, mature and cancerous gut, we combine current literature and in silico analyses from the TCGA-database, GTEX Project, E14.5 mouse intestine and enteric neural crest cells, and an RNA-sequencing time-series of human embryonic colonic samples.
Major conclusions
This study reveals that all members display a differential expression pattern in the gut and that NDRG1, NDRG2 and NDRG4 (1) can serve as biomarker for …
学术搜索中的文章
N Vaes, SL Schonkeren, E Brosens, A Koch… - Biochimica et Biophysica Acta (BBA)-General Subjects, 2018