作者
S Hossein Fatemi, Teri J Reutiman, Timothy D Folsom, Paul D Thuras
发表日期
2009/2
期刊
Journal of autism and developmental disorders
卷号
39
页码范围
223-230
出版商
Springer US
简介
Gamma-aminobutyric acid A (GABAA) receptors are ligand-gated ion channels responsible for mediation of fast inhibitory action of GABA in the brain. Preliminary reports have demonstrated altered expression of GABA receptors in the brains of subjects with autism suggesting GABA/glutamate system dysregulation. We investigated the expression of four GABAA receptor subunits and observed significant reductions in GABRA1, GABRA2, GABRA3, and GABRB3 in parietal cortex (Brodmann’s Area 40 (BA40)), while GABRA1 and GABRB3 were significantly altered in cerebellum, and GABRA1 was significantly altered in superior frontal cortex (BA9). The presence of seizure disorder did not have a significant impact on GABAA receptor subunit expression in the three brain areas. Our results demonstrate that GABAA receptors are reduced in three brain regions that have previously been implicated in the …
引用总数
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学术搜索中的文章
SH Fatemi, TJ Reutiman, TD Folsom, PD Thuras - Journal of autism and developmental disorders, 2009