作者
Valerie Sung, Frank D’Amico, Michael D Cabana, Kim Chau, Gideon Koren, Francesco Savino, Hania Szajewska, Girish Deshpande, Christophe Dupont, Flavia Indrio, Silja Mentula, Anna Partty, Daniel Tancredi
发表日期
2018/1/1
来源
Pediatrics
卷号
141
期号
1
出版商
American Academy of Pediatrics
简介
OBJECTIVE:
Through an individual participant data meta-analysis, we sought to definitively determine if L reuteri DSM17938 effectively reduces crying and/or fussing time in infants with colic and whether effects vary by feeding type.
DATA SOURCES:
We searched online databases (PubMed, Medline, Embase, the Cumulative Index to Nursing and Allied Health Literature, the Database of Abstracts of Reviews of Effects, and Cochrane), e-abstracts, and clinical trial registries.
STUDY SELECTION:
These were double-blind randomized controlled trials (published by June 2017) of L reuteri DSM17398 versus a placebo, delivered orally to infants with colic, with outcomes of infant crying and/or fussing duration and treatment success at 21 days.
DATA EXTRACTION:
We collected individual participant raw data from included studies modeled simultaneously in multilevel generalized linear mixed-effects regression models …
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V Sung, F D'Amico, MD Cabana, K Chau, G Koren… - Pediatrics, 2018