作者
Janie F Shelton, Estella M Geraghty, Daniel J Tancredi, Lora D Delwiche, Rebecca J Schmidt, Beate Ritz, Robin L Hansen, Irva Hertz-Picciotto
发表日期
2014/10
期刊
Environmental health perspectives
卷号
122
期号
10
页码范围
1103-1109
出版商
NLM-Export
简介
Background: Gestational exposure to several common agricultural pesticides can induce developmental neurotoxicity in humans, and has been associated with developmental delay and autism.
Objectives: We evaluated whether residential proximity to agricultural pesticides during pregnancy is associated with autism spectrum disorders (ASD) or developmental delay (DD) in the Childhood Autism Risks from Genetics and Environment (CHARGE) study.
Methods: The CHARGE study is a population-based case–control study of ASD, DD, and typical development. For 970 participants, commercial pesticide application data from the California Pesticide Use Report (1997–2008) were linked to the addresses during pregnancy. Pounds of active ingredient applied for organophophates, organochlorines, pyrethroids, and carbamates were aggregated within 1.25-km, 1.5-km, and 1.75-km buffer distances from the home …
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