作者
Emilie A Uffman, Shuk Hang Li, Jui-Lin Chen, Noel Allen, Sefelani Boiditswe, Genevieve G Fouda, Jillian H Hurst, Mohamed Z Patel, Andrew P Steenhoff, Coleen K Cunningham, Emily Qin, Clemontina A Davenport, Matthew S Kelly
发表日期
2022/8/5
期刊
Vaccine
卷号
40
期号
33
页码范围
4764-4771
出版商
Elsevier
简介
Background
Streptococcus pneumoniae is a leading cause of severe infections among children. Despite vaccination, HIV-exposed, uninfected (HEU) children have a higher incidence of invasive pneumococcal disease than HIV-unexposed, uninfected (HUU) children. We sought to compare the immunogenicity of 13-valent pneumococcal conjugate vaccine (PCV-13) in HEU and HUU infants.
Methods
We conducted a prospective cohort study of 134 mother-infant dyads in Botswana. Infants received PCV-13 doses at 2, 3, and 4 months through routine clinical care. We measured IgG antibodies specific to vaccine serotypes in sera collected from infants at 0, 5, and 12 months of age. We calculated the proportion of infants with protective IgG levels (≥0.35 µg/mL) to specific pneumococcal serotypes.
Results
At birth, fewer than half of infants had protective IgG levels to serotypes 1 (38%), 3 (46%), 4 (33%), 5 (23%), 6B (40 …
引用总数
20242
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