作者
Jui-Lin Chen, Chelsea N Fries, Stella J Berendam, Nicole S Rodgers, Emily F Roe, Yaoying Wu, Shuk Hang Li, Rishabh Jain, Brian Watts, Joshua Eudailey, Richard Barfield, Cliburn Chan, M Anthony Moody, Kevin O Saunders, Justin Pollara, Sallie R Permar, Joel H Collier, Genevieve G Fouda
发表日期
2022/9/23
期刊
Science Advances
卷号
8
期号
38
页码范围
eabq0273
出版商
American Association for the Advancement of Science
简介
To develop vaccines for certain key global pathogens such as HIV, it is crucial to elicit both neutralizing and non-neutralizing Fc-mediated effector antibody functions. Clinical evidence indicates that non-neutralizing antibody functions including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) contribute to protection against several pathogens. In this study, we demonstrated that conjugation of HIV Envelope (Env) antigen gp120 to a self-assembling nanofiber material named Q11 induced antibodies with higher breadth and functionality when compared to soluble gp120. Immunization with Q11-conjugated gp120 vaccine (gp120-Q11) demonstrated higher tier 1 neutralization, ADCP, and ADCC as compared to soluble gp120. Moreover, Q11 conjugation altered the Fc N-glycosylation profile of antigen-specific antibodies, leading to a phenotype associated with …
学术搜索中的文章
JL Chen, CN Fries, SJ Berendam, NS Rodgers, EF Roe… - Science Advances, 2022