作者
Sandra S Ribeiro, Aline M de Jesus, Charlene S dos Anjos, Thanany B da Silva, Alan DC Santos, Jemmyson R de Jesus, Moacir S Andrade, Tais S Sampaio, Wesley F Gomes, Péricles B Alves, Adriana A Carvalho, Claudia Pessoa, Manoel O de Moraes, Maria LB Pinheiro, Ana Paula N Prata, Arie F Blank, Renata Silva-Mann, Valeria RS Moraes, Emmanoel V Costa, Paulo Cesar L Nogueira, Daniel P Bezerra
发表日期
2012/9
期刊
Planta Medica
卷号
78
期号
14
页码范围
1601-1606
出版商
Georg Thieme Verlag KG
简介
Plants are promising sources of new bioactive compounds. The aim of this study was to investigate the cytotoxic potential of nine plants found in Brazil. The species studied were: Annona pickelii Diels (Annonaceae), Annona salzmannii A. DC. (Annonaceae), Guatteria blepharophylla Mart. (Annonaceae), Guatteria hispida (R. E. Fr.) Erkens & Maas (Annonaceae), Hancornia speciosa Gomes (Apocynaceae), Jatropha curcas L. (Euphorbiaceae), Kielmeyera rugosa Choisy (Clusiaceae), Lippia gracilis Schauer (Verbenaceae), and Hyptis calida Mart. Ex Benth (Lamiaceae). Different types of extractions from several parts of plants resulted in 43 extracts. Their cytotoxicity was tested against HCT-8 (colon carcinoma), MDA-MB-435 (melanoma), SF-295 (glioblastoma), and HL-60 (promielocitic leukemia) human tumor cell lines, using the thiazolyl blue test (MTT) assay. The active extracts were those obtained from G …
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SS Ribeiro, AM de Jesus, CS dos Anjos, TB da Silva… - Planta Medica, 2012