作者
Alexander Zoufaly, M An der Heiden, C Kollan, JR Bogner, G Fätkenheuer, JC Wasmuth, M Stoll, O Hamouda, J van Lunzen, ClinSurv Study Group
发表日期
2011/2/1
期刊
Journal of Infectious Diseases
卷号
203
期号
3
页码范围
364-371
出版商
Oxford University Press
简介
Background. A subgroup of human immunodeficiency virus type 1 (HIV-1)–infected patients with severe immunodeficiency show persistently low CD4+ cell counts despite sustained viral suppression. It is unclear whether this immuno-virological discordance translates into an increased risk for clinical events.
Methods. Data analysis from a large multicenter cohort incorporating 14,433 HIV-1–infected patients in Germany. Treatment-naive patients beginning antiretroviral therapy (ART) with CD4+ cell counts <200 cells/μL who achieved complete and sustained viral suppression <50 copies/mL (n = 1318) were stratified according to the duration of immuno-virological discordance (failure to achieve a CD4+ cell count ≥200 cells/μL). Groups were compared by descriptive and Poisson statistics. The time-varying discordance status was analyzed in a multivariable Cox …
学术搜索中的文章
A Zoufaly, M An der Heiden, C Kollan, JR Bogner… - Journal of Infectious Diseases, 2011