作者
Rachael L DiSantostefano, Hao Li, David B Rubin, David A Stempel
发表日期
2013/1/1
期刊
BMJ open
卷号
3
期号
4
页码范围
e001838
出版商
British Medical Journal Publishing Group
简介
Objective
To identify subsets of chronic obstructive pulmonary disease (COPD) patients who are more protected from exacerbations with the use of an inhaled corticosteroid/long-acting β2 agonist (ICS/LABA) combination, compared with the use of LABA monotherapy.
Design
Post hoc cluster analysis of patients from two randomised clinical trials of salmeterol/fluticasone propionate (SFC) and salmeterol (SAL) that had primary endpoints of moderate/severe exacerbation rates.
Setting
Centres in North America.
Participants
1543 COPD patients were studied.
Interventions
SFC 50/250 µg or SAL 50 µg, twice daily.
Primary and secondary outcome measures
The analysis identified clusters of COPD patients more responsive to SFC versus SAL with respect to the annual rate of moderate/severe exacerbations and compared their baseline clinical characteristics.
Results
Overall, SFC significantly reduced the annual …
学术搜索中的文章
RL DiSantostefano, H Li, DB Rubin, DA Stempel - BMJ open, 2013