作者
Shanshan Li, Hyun Joon Shin, Eric L Ding, Rob M van Dam
发表日期
2009/7/8
来源
Jama
卷号
302
期号
2
页码范围
179-188
出版商
American Medical Association
简介
Context
The association of obesity with development of type 2 diabetes may be partly mediated by altered secretion of adipokines by adipose tissue. Greater adiposity down-regulates secretion of adiponectin, an adipokine with anti-inflammatory and insulin-sensitizing properties. The strength and consistency of the relation between plasma adiponectin and risk of type 2 diabetes is unclear.
Objective
To systematically review prospective studies of the association of plasma adiponectin levels and risk of type 2 diabetes.
Data Sources
A systematic search of the MEDLINE, EMBASE, and Science Citation Index Expanded databases using adiponectin and diabetes and various synonyms and reference lists of retrieved articles up to April 10, 2009.
Study Selection
We included prospective studies with plasma adiponectin levels as the exposure and incidence of type 2 diabetes as the outcome variable.
Data Extraction
Two …
引用总数
学术搜索中的文章
S Li, HJ Shin, EL Ding, RM van Dam - Jama, 2009