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Methods:

Five-year (2013–2017) review of coagulopathic trauma patients at our Level-I trauma center who received 3-or 4-PCC. Patients were divided into two groups (4-PCC and 3-PCC) and matched in 1: 1 ratio using propensity-score-matching for demographics, injury parameters, admission vitals, and hematological parameters. Primary outcomes were time to correction of international normalized ratio (INR), blood products transfusion, thromboembolic complications, and mortality. Secondary outcomes were hospital-length of stay (LOS), intensive care unit (ICU)-LOS, cost of therapy, and total hospital cost.

Results:

Six hundred fifty-seven patients met inclusion criteria of whom 250 patients (4-PCC: 125; 3-PCC: 125) were matched. The mean age was 50±19.4 y, 64% were male, and median-injury severity score was 24 [15–33]. 4-PCC was associated with accelerated correction of INR (365 vs. 428 min, P= 0.01 …