作者
Lurdes Gano, Teresa Pinheiro, António P Matos, Francisco Tortosa, Tiago F Jorge, Maria S Gonçalves, Marta Martins, Tânia S Morais, Andreia Valente, Ana I Tomaz, Maria H Garcia, Fernanda Marques
发表日期
2019/7/1
期刊
Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents)
卷号
19
期号
10
页码范围
1262-1275
出版商
Bentham Science Publishers
简介
Background
Ruthenium complexes have been extensively investigated for their prospective value as alternatives to cisplatin. Recently, we reported the in vitro anticancer properties of a family of organometallic ruthenium( II)-cyclopentadienyl complexes and have explored their mechanism of action.
Objective
The purpose of this study was to evaluate the in vivo antitumour efficacy and toxicity of one of these Ru(II) compounds, [RuCp(mTPPMSNa)(2,2′-bipy)][CF3SO2] (TM85) which displayed an interesting spectrum of activity against several cancer cells.
Methods
Studies to assess the antitumour activity and toxicity were performed in a metastatic prostate (PC3) mice model using ICP-MS, nuclear microscopy, elemental analysis and Transmission Electron Microscopy (TEM).
Results
TM85 showed low systemic toxicity but no significant tumour reduction, when administered at tolerated dose (20mg/kg) over 10 days …
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L Gano, T Pinheiro, AP Matos, F Tortosa, TF Jorge… - Anti-Cancer Agents in Medicinal Chemistry (Formerly …, 2019