作者
Seung-Jung Park, Soo-Jin Kang, Jung-Min Ahn, Eun Bo Shim, Young-Tae Kim, Sung-Cheol Yun, Haegeun Song, Jong-Young Lee, Won-Jang Kim, Duk-Woo Park, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Gary S Mintz, Seong-Wook Park
发表日期
2012/10
期刊
JACC: Cardiovascular Interventions
卷号
5
期号
10
页码范围
1029-1036
出版商
American College of Cardiology Foundation
简介
Objectives
The goal of this study was to identify clinical and lesion-specific local factors affecting visual-functional mismatch.
Background
Although lesion severity determined by coronary angiography has not been well correlated with physiological significance, the mechanism of the discordance remains poorly understood.
Methods
The authors assessed quantitative coronary angiography, intravascular ultrasound (IVUS), and fractional flow reserve (FFR) in a prospective cohort of 1,000 patients with 1,129 coronary lesions. Three-dimensional computational simulation studies were performed.
Results
Lesions with angiographic diameter stenosis (DS) ≥50% and FFR >0.80 (“mismatches”) were seen in 57% of non–left main lesions and in 35% of the left main lesions, respectively (p = 0.032). Conversely, among the lesions with DS <50% and FFR <0.80 (“reverse mismatches”) 16% were found in the non–left main …
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SJ Park, SJ Kang, JM Ahn, EB Shim, YT Kim, SC Yun… - JACC: Cardiovascular Interventions, 2012