作者
Liwei Cao*, Chen Huang*, Daniel Cui Zhou*, Yingwei Hu, T Mamie Lih, Sara R Savage, Karsten Krug, David J Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, Nadezhda V Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A Wyczalkowski, Hariharan Easwaran, Ludmila Danilova, Arvind Singh Mer, Seungyeul Yoo, Joshua M Wang, Wenke Liu, Benjamin Haibe-Kains, Mathangi Thiagarajan, Scott D Jewell, Galen Hostetter, Chelsea J Newton, Qing Kay Li, Michael H Roehrl, David Fenyö, Pei Wang, Alexey I Nesvizhskii, DR Mani, Gilbert S Omenn, Emily S Boja, Mehdi Mesri, Ana I Robles, Henry Rodriguez, Oliver F Bathe, Daniel W Chan, Ralph H Hruban, Li Ding, Bing Zhang, Hui Zhang
发表日期
2021/9/16
期刊
Cell
卷号
184
期号
19
页码范围
5031-5052. e26
出版商
Cell Press
简介
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient survival. Toward understanding the underlying molecular alterations that drive PDAC oncogenesis, we conducted comprehensive proteogenomic analysis of 140 pancreatic cancers, 67 normal adjacent tissues, and 9 normal pancreatic ductal tissues. Proteomic, phosphoproteomic, and glycoproteomic analyses were used to characterize proteins and their modifications. In addition, whole-genome sequencing, whole-exome sequencing, methylation, RNA sequencing (RNA-seq), and microRNA sequencing (miRNA-seq) were performed on the same tissues to facilitate an integrated proteogenomic analysis and determine the impact of genomic alterations on protein expression, signaling pathways, and post-translational modifications. To ensure robust downstream analyses, tumor neoplastic cellularity was assessed via …
学术搜索中的文章
L Cao, C Huang, DC Zhou, Y Hu, TM Lih, SR Savage… - Cell, 2021