作者
Hongji Pu, Qun Huang, Xing Zhang, Zhaoyu Wu, Peng Qiu, Yihong Jiang, Ruihan Wang, Zhen Zhao, Zhijue Xu, Jinbao Qin, Xinwu Lu, Weimin Li
发表日期
2022/4/1
来源
Journal of Vascular Surgery
卷号
75
期号
4
页码范围
1440-1449. e5
出版商
Mosby
简介
Objective
Atherosclerosis obliterans (ASO) is a chronic occlusive arterial disease and the most common type of peripheral arterial disease. Current treatment options like medication and vascularization have limited effects for “no-option” patients, and stem cell therapy is considered a viable option, although its application and efficacy have not been standardized. The objective of this review was to assess the safety and efficacy of autologous stem cell therapy in patients with ASO.
Methods
We performed a literature search of published randomized controlled trials (RCTs) for patients with ASO receiving stem cell therapy without a revascularization option. PubMed, Embase, and the Cochrane Library were searched. This study was conducted by a pair of authors independently and audited by a third author. Data were synthesized with a random-effects model.
Results
A total of 630 patients in 12 RCTs were included. The …
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H Pu, Q Huang, X Zhang, Z Wu, P Qiu, Y Jiang… - Journal of Vascular Surgery, 2022