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Biocontamination of medical devices and implants is a growing issue that causes medical complications and increased expenses. In the fight against biocontamination, developing synthetic surfaces, which reduce the adhesion of microbes and provide biocidal activity or combinatory effects, has emerged as a major global strategy. Advances in nanotechnology and biological sciences have made it possible to design smart surfaces for decreasing infections. Nevertheless, the clinical performance of these surfaces is highly depending on the choice of material. This review focuses on the antimicrobial surfaces with functional material coatings, such as cationic polymers, metal coatings and antifouling micro-/nanostructures. One of the highlights of the review is providing insights into the virus-inactivating surface development, which might particularly be useful for controlling the currently confronted pandemic coronavirus disease 2019 (COVID-19). The nanotechnology-based strategies presented here might be beneficial to produce materials that reduce or prevent the transmission of airborne viral droplets, once applied to biomedical devices and protective equipment of medical workers. Overall, this review compiles existing studies in this broad field by focusing on the recent related developments, draws attention to the possible activity mechanisms, discusses the key challenges and provides future recommendations for developing new, efficient antimicrobial and antiviral surface coatings.