作者
Anne-Sophie Pulcrano-Nicolas, Carole Proust, Frédéric Clarençon, Alice Jacquens, Claire Perret, Maguelonne Roux, Eimad Shotar, Florian Thibord, Louis Puybasset, Sophie Garnier, Vincent Degos, David-Alexandre Trégouët
发表日期
2018/9
期刊
Stroke
卷号
49
期号
9
页码范围
2220-2223
出版商
Lippincott Williams & Wilkins
简介
Background and Purpose
Arterial vasospasm is a well-known delayed complication of aneurysmal subarachnoid hemorrhage (aSAH). However, no validated biomarker exists to help clinicians discriminating patients with aSAH who will develop vasospasm (VSP+) and identifying those who then deserve aggressive preventive therapy. We hypothesized that whole-blood miRNAs could be a source of candidate biomarkers for vasospasm.
Methods
Using a next-generation sequencing approach, we performed whole-blood miRNA profiling between VSP+patients with aSAH and patients who did not develop vasospasm (VSP−) in a prospective cohort of 32 patients. Profiling was performed on the admission day and 3 days before vasospasm.
Results
Four hundred forty-two miRNAs were highly expressed in whole blood of patients with aSAH. Among them, hsa-miR-3177-3p demonstrated significant (P=5.9×10−5; P …
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AS Pulcrano-Nicolas, C Proust, F Clarençon… - Stroke, 2018