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Background  Ultraviolet radiations generate reactive oxygen species, leading to adverse effects on skin properties. Botanical extracts are multifunctional in nature having various properties like photoprotection, anti‐aging, moisturizing, antioxidant, astringent, anti‐irritant, and antimicrobial activity.

Aims  The aim of this study was to formulate creams having Curcuma longa extract loaded novel vesicular systems (liposomes, ethosomes, and transfersomes) and study their photoprotective effect by assessment of skin hydration (Cutometer) and sebum content (Sebumeter).

Methods  The alcoholic C. longa extract loaded liposomes, ethosomes, and transfersomes having 0.5–2.0% w/w extract were prepared, evaluated for size, entrapment efficiency, and incorporated into the cream. Their long‐term interaction with skin (6 weeks) was compared in terms of their effects on skin hydration and sebum content.

Results …