作者
Jordan W Smoller, Matthew Allison, Barbara B Cochrane, J David Curb, Roy H Perlis, Jennifer G Robinson, Milagros C Rosal, Nanette K Wenger, Sylvia Wassertheil-Smoller
发表日期
2009/12/14
期刊
Archives of internal medicine
卷号
169
期号
22
页码范围
2128-2139
出版商
American Medical Association
简介
Background
Antidepressants are commonly prescribed medications, but their effect on cardiovascular morbidity and mortality remains unclear.
Methods
Prospective cohort study of 136 293 community-dwelling postmenopausal women in the Women's Health Initiative (WHI). Women taking no antidepressants at study entry and who had at least 1 follow-up visit were included. Cardiovascular morbidity and all-cause mortality for women with new antidepressant use at follow-up (n = 5496) were compared with those characteristics for women taking no antidepressants at follow-up (mean follow-up, 5.9 years).
Results
Antidepressant use was not associated with coronary heart disease (CHD). Selective serotonin reuptake inhibitor (SSRI) use was associated with increased stroke risk (hazard ratio [HR],1.45, [95% CI, 1.08-1.97]) and all-cause mortality (HR,1.32 [95% CI, 1.10-1.59]). Annualized rates per 1000 person-years of …
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JW Smoller, M Allison, BB Cochrane, JD Curb… - Archives of internal medicine, 2009