作者
Maya Ghoussaini, David Meyre, Stéphane Lobbens, Guillaume Charpentier, Karine Clément, Marie-Aline Charles, Maïté Tauber, Jacques Weill, Philippe Froguel
发表日期
2005/12
期刊
BMC medical genetics
卷号
6
页码范围
1-8
出版商
BioMed Central
简介
Background
The Pro12Ala Single Nucleotide Polymorphism (SNP) of the Peroxisome Proliferator-Activated Receptor gamma 2 (PPAR-gamma 2) has been associated with insulin resistance and type 2 diabetes (T2D) and also inconsistently with obesity. The aim of this study was to evaluate the impact of this SNP with regards to T2D and childhood and adult obesity in the French Caucasian population.
Methods
We conducted three independent case/control studies encompassing 2126 cases and 1124 controls.
Results
We found a significant association between PPAR-gamma 2 Pro12Ala SNP and T2D (p = 0.04, OR = 1.37), which was stronger when the T2D cohort was stratified according to the obesity status (p = 0.03, OR = 1.81 in obese T2D subjects). In contrast, there was no association between the Pro12Ala SNP …
引用总数
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M Ghoussaini, D Meyre, S Lobbens, G Charpentier… - BMC medical genetics, 2005