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The actions of intracerebroventricularly infused histamine and selective histamine H₁, H₂ and H₃ receptor agonists on food and water intake and urine flow were studied in rats. It was found that 100–800 nmoles of histamine significantly suppressed feeding. The H₁ agonist 2-(3-trifluoromethylphenyl)histamine (FMPH) decreased food intake, whereas the H₂ agonist dimaprit was without effect. Histamine- and FMPH-induced suppressions of feeding were attenuated by blockade of H₁ but not by H₂ receptors. The results clearly demonstrate that activation of brain H₁ receptors decreases food intake. In subsequent studies, we found that both metoprine and thioperamide, which increase histaminergic activity through different mechanisms, also reduced food intake. This finding indicates that the brain histaminergic system is associated with feeding behavior. The same is true with body water homeostasis. Histamine …