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Effects of the histamine H₄ receptor antagonist JNJ 7777120 (1‐[(5‐chloro‐1H‐indol‐2‐yl)carbonyl]‐4‐methylpiperazine) were tested in two models of allergic contact dermatitis. Dermatitis was induced by 2,4‐dinitrochlorobenzene and toluene‐2,4‐diisocyanate, which differ in their Th1–Th2 profile in that way that 2,4‐dinitrochlorobenzene is a classical contact allergen with a pronounced Th1‐mediated inflammation, while the respiratory chemical allergen toluene‐2,4‐diisocyanate induces a Th2‐dominated inflammation. JNJ 7777120 (15 mg/kg) administered 2 h and 30 min before and 1 h after challenge did not reduce the hapten‐induced ear swelling determined 24 h after challenge. This was confirmed by histological evaluation of the ear skin. A repeated administration of the haptens to the rostral part of the back of sensitized animals resulted in a frequent scratching behaviour. An administration of JNJ …