作者
Mark Lazarev, Chengrui Huang, Alain Bitton, Judy H Cho, Richard H Duerr, Dermot P McGovern, Deborah D Proctor, Miguel Regueiro, John D Rioux, Philip P Schumm, Kent D Taylor, Mark S Silverberg, Hillary A Steinhart, Susan Hutfless, Steven R Brant
发表日期
2013/1/1
期刊
Official journal of the American College of Gastroenterology| ACG
卷号
108
期号
1
页码范围
106-112
出版商
LWW
简介
OBJECTIVES:
In classifying Crohn's disease (CD) location, proximal (L4) disease includes esophagogastroduodenal (EGD) and jejunal disease. Our aim was to determine the influence of proximal disease on outcomes of behavior and need for surgery and to determine if there was significant clinical heterogeneity between EGD and jejunal disease.
METHODS:
We performed a cross-sectional query of the NIDDK (National Institute of Diabetes and Digestive and Kidney Disease) Inflammatory Bowel Disease Genetics Consortium (IBDGC) database of patients with a confirmed diagnosis of CD and phenotyped per the IBDGC manual. Presence of any L4, L4-EGD, L4-jejunal, and non-L4 disease (L1-ileal, L2-colonic, and L3-ileocolonic) was compared with demographic features including age, race, ethnicity, smoking and inflammatory bowel disease (IBD) family history, diagnosis age, disease duration, clinical …
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M Lazarev, C Huang, A Bitton, JH Cho, RH Duerr… - Official journal of the American College of …, 2013