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The exact influence of sleep-related breathing disorder (SRBD) on blood pressure control remains unknown. We investigated the influence of different degrees of SRBD on daytime blood pressure and its association to documented hypertension by examining 1,190 consecutive patients referred for diagnosis of SRBD. The protocol includes clinical interview, physical examination, office blood pressure measurement, cholesterol, and blood gas analysis. Unattended home monitoring of nocturnal breathing was performed for assessment of SRBD activity (respiratory disturbance index [RDI]). RDI was independently and linearly associated with systolic blood pressure (unstandardized coefficient [B] = 0.07 ± 0.03, p = 0.03), diastolic blood pressure (B = 0.07 ± 0.02, p = 0 < 0.001), and heart rate (B = 0.10 ± 0.02, p < 0.001) at rest. The relative risk for hypertension (blood pressure ⩾ 160/95 mm Hg …