作者
Carina Graversen, Søren S Olesen, Anne E Olesen, Kristoffer Steimle, Dario Farina, Oliver HG Wilder‐Smith, Stefan AW Bouwense, Harry van Goor, Asbjørn M Drewes
发表日期
2012/3
期刊
British journal of clinical pharmacology
卷号
73
期号
3
页码范围
363-372
出版商
Blackwell Publishing Ltd
简介
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT
• Pregabalin is an anticonvulsive agent prescribed as a secondary analgesic for patients when standard pain treatment is insufficient.
• The analgesic effect resides in the central nervous system.
• The central analgesic effect can be evaluated by electroencephalography.
WHAT THIS STUDY ADDS
• The analgesic effect of pregabalin is reflected as a slowing of brain oscillations.
• The slowing of brain oscillations for each individual patient is correlated with subjective pain scores.
• The developed methodology may be used as a mechanistic approach to monitor the analgesic effect of pregabalin in pharmacological studies.
AIM To identify electroencephalographic (EEG) biomarkers for the analgesic effect of pregabalin in patients with chronic visceral pain.
METHODS This was a double‐blind, placebo‐controlled study in 31 patients suffering from visceral …
学术搜索中的文章
C Graversen, SS Olesen, AE Olesen, K Steimle… - British journal of clinical pharmacology, 2012