作者
Lars Arendt-Nielsen, Anne E Olesen, Camilla Staahl, Frédérique Menzaghi, Sherron Kell, Gilbert Y Wong, Asbjørn M Drewes
发表日期
2009/9/1
期刊
The Journal of the American Society of Anesthesiologists
卷号
111
期号
3
页码范围
616-624
出版商
The American Society of Anesthesiologists
简介
Background
Peripherally selective opioids may be beneficial in visceral pain management due to absence of centrally mediated side effects. The objectives of this study were: (1) to assess the effects of a peripherally selective tetrapeptide kappa-opioid receptor agonist, CR665, on experimental pain from multi-modal stimulation of skin, muscle, and viscera, and (2) contrast these effects with those of oxycodone (centrally acting opioid).
Methods
The study was designed as a single-center, single-dose, randomized, double-blind, placebo and active-controlled, double-dummy, three-way, crossover study in healthy males. Subjects received the following treatments in randomized order: (1) CR665 (0.36 mg/kg) administered intravenously over 1 h, (2) oxycodone (15 mg) administered orally, and (3) placebo administered intravenously and orally. The following pain tests were used: (1 …
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