作者
Jeong-Hoon Lee, Yuri Cho, Hwi Young Kim, Eun Ju Cho, Dong Hyeon Lee, Su Jong Yu, Jae Woo Lee, Nam-Joon Yi, Kwang-Woong Lee, Seoung Hoon Kim, Jong Man Kim, Jae-Won Joh, Lewis W Teperman, James S Park, Yoon Jun Kim, Kyung-Suk Suh, Jung-Hwan Yoon
发表日期
2016/5/1
期刊
Annals of surgery
卷号
263
期号
5
页码范围
842-850
出版商
LWW
简介
Objective:
To develop and validate a model to predict tumor recurrence after living donor liver transplantation (LDLT)(MoRAL) for hepatocellular carcinoma (HCC) beyond the Milan criteria (MC).
Background:
Some subgroups of HCC exceeding the MC experience substantial benefit from LDLT.
Methods:
This multicenter study included a total of 566 consecutive patients who underwent LDLT in Korea: the beyond-MC cohort (n= 205, the derivation [n= 92] and validation [n= 113] sets) and the within-MC cohort (n= 361). The primary endpoint was time-to-recurrence.
Results:
Using multivariate Cox proportional hazard model, we derived the MoRAL score using serum levels of protein induced by vitamin K absence-II and alpha-fetoprotein, which provided a good discriminant function on time-to-recurrence (concordance index= 0.88). Concordance index was maintained similarly on both internal and external validations …
学术搜索中的文章
JH Lee, Y Cho, HY Kim, EJ Cho, DH Lee, SJ Yu… - Annals of surgery, 2016
