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The influence of exposure to lead on the frequency of micronuclei (MN), nuclear buds and nucleoplasmatic bridges was investigated in peripheral blood lymphocytes in 15 male battery‐manufacturing workers and 15 controls matched for age and smoking habits. In addition to MN test, blood lead (B‐Pb) and cadmium (B‐Cd), delta aminolevulinic acid dehydratase (ALAD) activity, erythrocyte protoporphyrin (EP), serum vitamin B₁₂ (S‐Vit B₁₂) and folate (S‐folate) were determined in all subjects. Lead‐exposed subjects had significantly higher MN frequency and B‐Pb concentrations than controls. In control smokers we found a significant negative correlation between B‐Pb concentration and frequency of nucleoplasmatic bridges, and nuclear division index. In control non‐smokers a significant positive correlation was observed only between age and nuclear buds frequency, and between S‐folate and B‐Pb level. In …