作者
Mirta Milić, Marcello Ceppi, Marco Bruzzone, Amaya Azqueta, Gunnar Brunborg, Roger Godschalk, Gudrun Koppen, Sabine Langie, Peter Møller, João Paulo Teixeira, Avdulla Alija, Diana Anderson, Vanessa Andrade, Cristina Andreoli, Fisnik Asllani, Ezgi Eyluel Bangkoglu, Magdalena Barančoková, Nursen Basaran, Elisa Boutet-Robinet, Annamaria Buschini, Delia Cavallo, Cristiana Costa Pereira, Carla Costa, Solange Costa, Juliana Da Silva, Cristian Del Boˊ, Vesna Dimitrijević Srećković, Ninoslav Djelić, Malgorzata Dobrzyńska, Zdenka Duračková, Monika Dvořáková, Goran Gajski, Serena Galati, Omar García Lima, Lisa Giovannelli, Irina A Goroshinskaya, Annemarie Grindel, Kristine B Gutzkow, Alba Hernández, Carlos Hernández, Kirsten B Holven, Idoia Ibero-Baraibar, Inger Ottestad, Ela Kadioglu, Alena Kažimirová, Elena Kuznetsova, Carina Ladeira, Blanca Laffon, Palma Lamonaca, Pierre Lebailly, Henriqueta Louro, Tania Mandina Cardoso, Francesca Marcon, Ricard Marcos, Massimo Moretti, Silvia Moretti, Mojgan Najafzadeh, Zsuzsanna Nemeth, Monica Neri, Bozena Novotna, Irene Orlow, Zuzana Paduchova, Susana Pastor, Hervé Perdry, Biljana Spremo-Potparević, Dwi Ramadhani, Patrizia Riso, Paula Rohr, Emilio Rojas, Pavel Rossner, Anna Safar, Semra Sardas, Maria João Silva, Nikolay Sirota, Bozena Smolkova, Marta Staruchova, Rudolf Stetina, Helga Stopper, Ekaterina I Surikova, Stine M Ulven, Cinzia Lucia Ursini, Vanessa Valdiglesias, Mahara Valverde, Pavel Vodicka, Katarina Volkovova, Karl-Heinz Wagner, Lada Živković, Maria Dušinská, Andrew R Collins, Stefano Bonassi
发表日期
2021/1/1
来源
Mutation Research/Reviews in Mutation Research
卷号
787
页码范围
108371
出版商
Elsevier
简介
The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification of those factors that can explain the large inter-individual and inter-laboratory variation. International collaborative initiatives such as the hCOMET project - a COST Action launched in 2016 - represent a valuable tool to meet this challenge. The aims of hCOMET were to establish reference values for the level of DNA damage in humans, to investigate the effect of host factors, lifestyle and exposure to genotoxic agents, and to compare different sources of assay variability. A database of 19,320 subjects was generated, pooling data from 105 studies run by 44 laboratories in 26 countries between 1999 and 2019. A mixed random effect log-linear model, in parallel with a classic meta-analysis, was applied to take …
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M Milić, M Ceppi, M Bruzzone, A Azqueta, G Brunborg… - Mutation Research/Reviews in Mutation Research, 2021