作者
Paul W Sperduto, Brian De, Jing Li, David Carpenter, John Kirkpatrick, Michael Milligan, Helen A Shih, Tugce Kutuk, Rupesh Kotecha, Hajime Higaki, Manami Otsuka, Hidefumi Aoyama, Malie Bourgoin, David Roberge, Salah Dajani, Sean Sachdev, Jordan Gainey, John M Buatti, William Breen, Paul D Brown, Lisa Ni, Steve Braunstein, Matthew Gallitto, Tony JC Wang, Ryan Shanley, Emil Lou, Jay Shiao, Laurie E Gaspar, Satoshi Tanabe, Toshimichi Nakano, Yi An, Veronica Chiang, Liang Zeng, Hany Soliman, Hesham Elhalawani, Daniel Cagney, Evan Thomas, Drexell H Boggs, Manmeet S Ahluwalia, Minesh P Mehta
发表日期
2022/9/1
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
114
期号
1
页码范围
60-74
出版商
Elsevier
简介
Purpose
Patients with lung cancer and brain metastases represent a markedly heterogeneous population. Accurate prognosis is essential to optimally individualize care. In prior publications, we described the graded prognostic assessment (GPA), but a GPA for patients with small cell lung cancer (SCLC) has never been reported, and in non-small cell lung cancer (NSCLC), the effect of programmed death ligand 1 (PD-L1) was unknown. The 3-fold purpose of this work is to provide the initial report of an SCLC GPA, to evaluate the effect of PD-L1 on survival in patients with NSCLC, and to update the Lung GPA accordingly.
Methods and Materials
A multivariable analysis of prognostic factors and treatments associated with survival was performed on 4183 patients with lung cancer (3002 adenocarcinoma, 611 nonadenocarcinoma, 570 SCLC) with newly diagnosed brain metastases between January 1, 2015, and …
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PW Sperduto, B De, J Li, D Carpenter, J Kirkpatrick… - International Journal of Radiation Oncology* Biology …, 2022