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Sunflower (Helianthus annuus) is an annual plant intensively cultivated as traditional oil crop being considered one of largest sources of vegetable oils. However, sunflower is represent a well-known herb used as antiinflammatory, cathartic, diuretic, emollient, expectorant, stimulant, vermifuge, antimalarial, anti-asthmatic, anti-oxidant, anti-tumor and antimicrobial agent and for cosmetics. In folk medicine, the sunflower seed are used in therapy of pulmonary disorders (sinusitis, bronchitis, pleuritis, laryngitis), different other types of infection (eye infections, whitlow, etc), thrombophlebitis, abscess, catarrh, blindness, diarrhea, dysentery, dysuria, rheumatism, hemorrhoids, fever, toothache, menorrhagia, scorpion stings, snakebite, inflammation, urogenital ailments, splenitis, aroma therapy, leg ulcer, etc.[1]. Plant represents an important source of oleic acid and linoleic acid, vitamins (E and B1 vitamin B5 and folate), alkaloids, glycosides, saponins, cardiac glycosides, tannins, phenolic, quercimeritrin, anthocyanin, cholin and betain and minerals (manganese, magnesium, copper, selenium, phosphorus)[2]. Phenolic compounds, the most important bioactive compounds from plant sources, are among the most potent and therapeutically useful bioactive substances, providing health benefits associated with reduced risk of chronic and degenerative disease. Recent research was focused on extraction of antioxidants from plants. The phenolic acids (chlorogenic acid or 5-O-caffeoyl-quinic acid, caffeic (4-hydroxycinnamic acid), gallic and p-coumaric acid are well known as bioactive classes of molecules with highly antitumoral, antibacterian, antiinflammatory …