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Computational imaging provides comprehensive and reliable information about human tissue for medical diagnosis and treatment, with medical image fusion as one of the most important technologies in the field. Empirical mode decomposition (EMD), a promising model for image processing, has been used for image fusion in some methods. However, the varying number of decomposed layers leads to problems using EMD for image fusion. In this article, we propose a fusion method for medical images incorporating L2 -norm-based features, a match/salience/fuzzy-weighted measure, and the 2-D Littlewood-Paley empirical wavelet transform (2-D LPEWT) as new version of EMD. We first decompose medical images with LPEWT to obtain the residual component (residue) and detailed sub-images that are named as intrinsic mode functions (IMFs). Then we extract the regional features of residue with an L2-norm …