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Primary Examiner—Christopher M. Babic Assistant Examiner—Jeremy C Flinders (74) Attorney, Agent, or Firm—Graeser Associates International Inc.; Dvorah Graeser (57) ABSTRACT A method for manufacturing synthetic genes and combinato rial DNA and protein libraries, termed here Divide and Con quer-DNA synthesis (D&C-DNA synthesis) method. The method can be used in a systematic and automated way to synthesize any long DNA molecule and, more generally, any combinatorial molecular library having the mathematical property of being a regular set of strings. The D&C-DNA synthesis method is an algorithm design paradigm that works by recursively breaking down a problem into two or more sub-problems of the same type. The division of long DNA sequences is done in silico. The assembly of the sequence is done in vitro. The D&C-DNA synthesis method protocol consists of a tree, in which each …