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Bacterial infections instigated by antibiotic-resistant bacteria are considered perilous health threats in today’s world due to their fast-increasing nature and the fewer availability of new treatment strategies. The properties of nanomaterials triggered by external stimuli are considered an encouraging technique for the remediation of antibacterial infectious diseases by producing photoinduced reactive oxygen species (ROS). Light-mediated treatment using zinc oxide (ZnO)-based nanohybrids leads the field with high interest in terms of sensitization of antibiotics and their targeted delivery. Moreover, the dual sensitization in a hybrid system could produce more efficacy as this phenomenon has been implemented in dye sensitized solar cells and photocatalysis. However, most of those hybrids are complicated and non-biocompatible. The present study highlights a tri-hybrid by encapsulating tetracycline (TC) in Au …