作者
Susana Gonzalez, Anupama Gupta, Jianfeng Cheng, Christina Tennyson, Suzanne K Lewis, Govind Bhagat, Peter HR Green
发表日期
2010/10/1
期刊
Gastrointestinal endoscopy
卷号
72
期号
4
页码范围
758-765
出版商
Mosby
简介
BACKGROUND
Studies have demonstrated that villous atrophy in celiac disease is patchy and have suggested that duodenal bulb biopsies aid in diagnosis.
OBJECTIVE
To determine the role of the addition of duodenal bulb biopsies to distal duodenum (D2) biopsies in the diagnosis of celiac disease.
DESIGN
Prospective, case-control study.
SETTING
Tertiary referral hospital.
PATIENTS
Patients undergoing upper endoscopy with biopsy for diagnosis or follow-up of celiac disease and control patients.
INTERVENTIONS
Blinded review of duodenal biopsy samples.
MAIN OUTCOME MEASUREMENTS
Increasing the yield as well as accuracy of the histologic diagnosis of celiac disease with the addition of bulb biopsies.
RESULTS
Of 128 patients enrolled in the study, 67 had celiac disease. Of 1079 biopsy specimens, only 319 (30%) were adequate for complete histologic analysis, resulting in 40 celiac patients and …
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S Gonzalez, A Gupta, J Cheng, C Tennyson, SK Lewis… - Gastrointestinal endoscopy, 2010