作者
Tamas A Gonda, Michael P Glick, Amrita Sethi, John M Poneros, Walter Palmas, Shahzad Iqbal, Susana Gonzalez, Subhadra V Nandula, Jean C Emond, Robert S Brown, Vundavalli V Murty, Peter D Stevens
发表日期
2012/1/1
期刊
Gastrointestinal endoscopy
卷号
75
期号
1
页码范围
74-79
出版商
Mosby
简介
BACKGROUND
The diagnosis of indeterminate biliary strictures is limited because of the low sensitivity of cytology. However, an accurate diagnosis of malignancy is critical in the management of patients with suspected biliary malignancy. Testing for chromosomal aneuploidy by fluorescence in situ hybridization (FISH) may increase the yield.
OBJECTIVE
To evaluate the diagnostic accuracy of FISH in indeterminate biliary strictures and the additional value of including deletion of 9p21 (p16) in the diagnostic criteria of malignant biliary strictures.
DESIGN
Retrospective review.
SETTING
Academic medical center.
PATIENTS
This study involved 76 consecutive patients who were seen for the evaluation of indeterminate strictures at our institution. These patients were screened, and 50 patients with either a final pathologic diagnosis or ≥12 months' conclusive follow-up were included in the analysis.
MAIN OUTCOME …
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TA Gonda, MP Glick, A Sethi, JM Poneros, W Palmas… - Gastrointestinal endoscopy, 2012