作者
An Pan, Qi Sun, Olivia I Okereke, Kathryn M Rexrode, Frank B Hu
发表日期
2011/9/21
来源
Jama
卷号
306
期号
11
页码范围
1241-1249
出版商
American Medical Association
简介
Context
Several studies have suggested that depression is associated with an increased risk of stroke; however, the results are inconsistent.
Objective
To conduct a systematic review and meta-analysis of prospective studies assessing the association between depression and risk of developing stroke in adults.
Data Sources
A search of MEDLINE, EMBASE, and PsycINFO databases (to May 2011) was supplemented by manual searches of bibliographies of key retrieved articles and relevant reviews.
Study Selection
We included prospective cohort studies that reported risk estimates of stroke morbidity or mortality by baseline or updated depression status assessed by self-reported scales or clinician diagnosis.
Data Extraction
Two independent reviewers extracted data on depression status at baseline, risk estimates of stroke, study quality, and methods used to assess depression and stroke. Hazard ratios (HRs) were …
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