作者
Shane Browne, Samir Hossainy, Kevin Healy
发表日期
2019/12/24
期刊
ACS Biomaterials Science & Engineering
卷号
6
期号
2
页码范围
1135-1143
出版商
American Chemical Society
简介
In situ-forming hydrogels present a promising approach for minimally invasive cell transplantation and tissue regeneration. Among prospective materials, hyaluronic acid (HyA) has displayed great potential, owing to its inherent biocompatibility, biodegradation, and ease of chemical modification. However, current studies in the literature use a broad range of HyA macromer molecular weights (MWs) from <100 kDa to 1 MDa with no consensus regarding an optimal MW for a specific application. We investigated the effects of different HyA macromer MWs on key biophysical properties of semisynthetic hydrogels, such as viscosity, gelation time, shear storage modulus, molecular diffusion, and degradation. Using higher-MW HyA macromers leads to quicker gelation times and stiffer, more stable hydrogels with smaller mesh sizes. Assessment of the potential for HyA hydrogels to support network formation by …
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S Browne, S Hossainy, K Healy - ACS Biomaterials Science & Engineering, 2019